Aurora Essay Research Paper Aurora Biosciences Corp

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Aurora Essay, Research Paper Aurora Biosciences Corp. (ABSC) April 21, 2000 This is one of those picket and shovel companies in the Biotechnology sector. ABSC designs and develops drug discovery technologies and services. Aurora Biosciences is developing a system using fluorescent assay technologies and ultra-high-throughput screening systems (UHTSS) to allow researchers to overcome many limitations of traditional drug discovery processes. Aurora’s functional genomics technology can successfully analyze over half a billion discrete cells derived from 20 million independent GenomeScreen(TM) clones in one day. It’s GenomeScreen(TM) technology acts as a search engine to rapidly scan the genome of living, human cells to find genes associated with specified diseases or

physiological processes. ABSC has technology capable of searching through expansive libraries of compounds to identify those that might lead to new medicines. This enables Aurora to rapidly identify commercially relevant genes, and to directly develop screens for drug discovery, faster and more efficiently than existing methods. To date, Aurora has filed for patent protection on over 100 previously unknown gene sequences, including their use for compound screening, human diagnostics and drug discovery. Genome, what is it? ge+nome – set of chromosomes: the full complement of genetic information that an individual organism inherits from its parents, especially the set of chromosomes and the genes they carry. A genome is the complete collection of an organism’s genetic material.

The human genome is made of about 50,000 to 100,000 genes located on the 23 pairs of chromosomes in a human cell. A single human chromosome may contain more than 250 million DNA base pairs, and it is estimated that the entire human genome consists of about 3 billion base pairs. Genetic information is found in each cell of the body, encoded in the chemical deoxyribonucleic acid (DNA). The ultimate goal of genomic mapping and sequencing is to associate specific human traits and inherited diseases with genes at locations on the chromosomes. The successful completion of the genome project will provide a better understanding of the organization of human genes and chromosomes. It promises to revolutionize both therapeutic and preventive medicine by providing insights into the basic

biochemical processes that cause many Human diseases. Celera (CRA) will soon reveal the sequence of the genome. When completed it will steer to a new great scientific challenge. The big commercial challenge after the completion of the genome will be to understand the function of the genes identified. (This market will be colossal) Aurora stands at the crossroads of this challenge by conducting the gene discovery while at the same time assigning function information to the genes. With their GenomeScreen technology, they’re in the business of discovering what genes actually do. So a challenge to sequence-based patents would likely heat up demand for Aurora’s technology. (Ok, it gets complicated here so just bare with me) Currently, about 20% of discovery programs are based on

genomics. In fact, it has been predicted that virtually all new discovery programs will be genomics based in a few years. A major challenge for the pharmaceutical industry is to determine which of these targets is significant from the drug discovery perspective (meaning $$$). To do this, companies must assign functions to the targets (what it does). Once the target has been identified, you still have to build a screen to find drugs that affect the target, a process which takes up to a year. Aurora’s Genomics and Molecular Biology division has developed a technology to overcome these challenges. The value that Aurora brings to this process is added at all stages, from gene identification to target validation to screening compounds to the compounds themselves. In other words, it